Project at a glance

Proteostasis and microtubule cytoskeleton

In our lab we challenge the central dogma postulating that regulation of gene expression and protein quantity is a unidirectional process. Our favourite proteins are tubulins - the main constituents of the microtubule cytoskeleton. We have recently shown how tubulin protein quantity feeds back into its encoding mRNA stability via a specificity factor.

Our goal is to dissect the molecular mechanisms that govern tubulin protein quantity control using biochemical and structural approaches, transcriptomics, and genome-wide screening. To address the functional aspects of protein quantity control, we deploy fluorescent imaging of live and fixed mammalian cultured cells.