The laboratory employs integrative methodologies alongside rodent models, combined with in vitro investigations, computational approaches, and human patient cohorts to examine how brown and beige fat cells within white adipose tissue regulate metabolism. Their objectives include creating innovative approaches to enhance insulin sensitivity, promote weight loss and fat browning, and elucidate the molecular mechanisms underlying physiological stimuli that enhance metabolic health. The research also emphasizes the immune system's role and gut microbiota-host signaling pathways in regulating energy balance. Recent discoveries include identifying physiological stimuli promoting fat browning, demonstrating gut microbiota contributions, and clarifying molecular interaction mechanisms. Additional research examines the gastrointestinal tract and methods for modulating its resorptive capacity.