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Estella Poloni
Department of Genetics and Evolution · Faculty of Science
Project at a glance
Pharmacogenomics and human evolution
The group examines genetic and genomic diversity origins in human populations, connecting these patterns to migration history and cultural developments including language evolution and subsistence strategy adoption. Research focuses on ADME genes—involved in drug Absorption, Distribution, Metabolism, and Excretion—as targets of natural or cultural selection due to their interface function between organisms and chemical/dietary environments. Methods include comparative analysis of diversity patterns across large population samples at genomic and specific genetic levels, GWAS approaches for investigating population variability in pharmacogenomics traits, and comparative studies in chimpanzees to understand functional roles of human polymorphisms in drug response regions.
Address
Anthropology Unit, Department of Genetics and Evolution, Sciences II - University of Geneva, Room 4-416, 4th floor, 30, quai Ernest-Ansermet, CH - 1211 Geneva 4
