The laboratory follows two main research lines. First, the group studies fundamental mechanisms governing mitosis and faithful chromosome segregation. They investigate how cells build and orient the mitotic spindle, control chromosome movements, and prevent segregation errors using human tissue culture cells, genetic tools, and quantitative microscopy. Collaboration with Monica Gotta examines the mitotic spindle in Caenorhabditis elegans embryos. Second, the group investigates how cell division deregulation links to human pathologies, particularly cancer and brain developmental defects. Frequent chromosome gain or loss during division causes aneuploidy, a cancer hallmark, and most microcephaly-related genes involve cell division. The team aims to dissect mechanistic origins of these defects and explore how aneuploidy could serve as anti-cancer targets. Collaborations include the HUG Oncology Department for cancer research and Denis Jabaudon for mouse genetics in brain cortex development.