Intracellular signaling governs numerous cellular activities in normal and pathological conditions. Research focuses on the evolutionary conserved Wnt/Frizzled signaling pathway, which is crucial for organism development but is also important in the adult, regulating stem cell proliferation, tissue regeneration, synapse formation, and when misactivated - cancer. Targeted pharmacological downregulation of the Wnt pathway is a priority in modern anticancer drug discovery programs. The laboratory is active in establishing novel paradigms for Wnt-targeting drug discovery and discovering novel molecular components of the Wnt pathway as potential drug targets. Numerous novel players involved in Wnt signaling have been discovered, some proving to be promising drug targets. Multiple lines of attack against the Wnt pathway in cancer have created an expanding portfolio of anti-Wnt signaling drug candidates at different stages of development.