Investigates how osteocytes orchestrate bone modeling and remodeling through periostin and related mechanisms. Research examines periostin's role in cortical bone response to mechanical loading and PTH administration, exploring its effects on sclerostin inhibition and Wnt-beta-catenin signaling. Studies involve mouse models of osteoporosis and biomechanical stimulation, with specific aims including examining periostin's effects on cathepsin K inhibition response, bone remodeling and osteocytic osteolysis, RANKL's role in skeletal mechanical loading response, and associations between serum periostin levels and bone microstructure in postmenopausal women. Results aim to enhance understanding of osteocyte and periostin functions in bone control and support development of novel osteoporosis therapeutics.