Master student position
Laboratory of Sandra Citi
Department of Cell Biology – Faculty of Sciences
Investigating the molecular basis of hypertension
The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and membrane proteins. Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize adherin-based junctions. PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through Genome-Wide Association Studies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells.
The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology.
Master, PhD and post-doctoral positions
Various iGE3 members
- Master student – Patrick Meraldi Group, Faculty of Medicine >>> Announcement
- Master student – Serge Nef Group, Faculty of Medicine >>> Announcement
- Master student – Xavier Perret Group, Faculty of Science >>> Announcement
- PhD student – Françoise Stutz Group, Faculty of Science >>> Contact
- PhD student – Post-doctoral fellow – Thanos Halazonetis Group, Faculty of Science >>> Details