The group investigates molecular mechanisms governing gonadal differentiation and testicular function. Research focuses on: (1) insulin signaling's role in sex determination and testicular function, examining how insulin family growth factors regulate male reproductive function through cell-lineage-specific studies using Cre/lox technology; (2) microRNA roles in testicular development, with evidence that Dicer and microRNAs are essential for spermatogenesis, where targeted ablation in germ cells or Sertoli cells causes infertility.