Francesco Negro Group
Department of Internal Medicine Specialties & Department of Pathology and Immunology
Faculty of Medicine, University of Geneva & Geneva University Hospitals
Project at a glance
Study of the pathogenesis of chronic hepatitis C, including both hepatic and extrahepatic manifestations
A particular regard is given to:
- HCV-induced fatty liver,
- HCV-induced insulin resistance,
- interactions between HCV and the metabolic syndrome,
- factors/mechanisms of liver disease progression and resistance to interferon alpha-based antiviral therapy (particularly host genetic and metabolic factors).
The above research is carried out through the following approaches:
- in vitro, using (i) different expression models of single HCV proteins (including lentivectors), (ii) full-length (infectious) HCV systems, (iii) co-cultures of HCV-expressing hepatoma cells with other celly types of major relevance in the pathogenesis of the metabolic syndrome;
- in vivo, using human tissues (liver and peripheral blood mononuclear cells), taken in the setting of various observational and interventional clinical trials.
Organization and conduct of the Swiss Hepatitis C Cohort Study, currently established as Foundation.