Department of Internal Medicine Specialties & Department of Pathology and Immunology
Geneva University Hospitals & University of Geneva
Service of Rheumatology
Geneva University Hospitals
26, Avenue Beau-Séjour
CH – 1211 Geneva 14
Phone: +41 (0)22 372 35 01
Fax: +41 (0)22 372 35 09
Project at a glance
My group has two main research interests.
- Clinical research on rheumatoid arthritis
- Basic research on the biology of cytokines of the interleukin-1 family
The clinical research is focused on questions related to genetic and environmental factors influencing the outcome of rheumatoid arthritis, the response to therapies, and factors influencing the occurrence of cardiovascular events in this patient population. For these studies, we have access to a large national cohort of patients with rheumatoid arthritis (approximately 6,000 patients) that includes different clinical measures of disease activity and severity, as well as radiographic measures of joint damage. In addition, we are establishing a biobank coupled to the clinical registry, which includes the collection of genomic DNA and serum.
My laboratory is interested in the regulation of expression and biological function of cytokines of the IL-1 family, in particular in the context of experimental models of inflammatory diseases. We have generated and are using different genetically modified mouse lines. We have a broad experience in models of arthritis and skin inflammation.